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Article

An essential role for the hematopoietic transcription factor Ikaros in hypothalamic–pituitary-mediated somatic growth

7 Feb 2006

Abstract excerpt

Ikaros transcription factors play critical functions in the control of lymphohematopoiesis and immune regulation. Family members contain multiple zinc fingers that mediate DNA binding and homooligomerization or heterooligomerization. Ikaros is abundantly expressed in pituitary mammosomatotrophs, where it deacetylates histone 3 sites on the proximal growth hormone (GH) promoter to silence gene expression....

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Identifiers

PMID: 16467156
DOI: 10.1073/pnas.0508565103

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Related research

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An essential role for the hematopoietic transcription factor Ikaros in hypothalamic–pituitary-mediated somatic growthPMID 16467156Read ↗

The role of the Ikaros gene in lymphocyte development and homeostasis.Semantic proximity Read ↗

Mice lacking the transcription factor Ikaros display behavioral alterations of an anti-depressive phenotype.Semantic proximity Read ↗

Ikaros is critical for B cell differentiation and function.Semantic proximity Read ↗

Ikaros isoforms: The saga continuesSemantic proximity Read ↗

Regulator of myeloid differentiation and function: The secret life of IkarosSemantic proximity Read ↗

The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouseSemantic proximity Read ↗

Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals.Semantic proximity Read ↗

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma.Semantic proximity Read ↗

The ikaros gene is required for the development of all lymphoid lineagesSemantic proximity Read ↗

Lack of Ikaros Deregulates Inflammatory Gene Programs in T CellsSemantic proximity Read ↗

Multiple functions of Ikaros in hematological malignancies, solid tumor and autoimmune diseasesSemantic proximity Read ↗

Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells.Semantic proximity Read ↗

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