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Article

Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.

Molecular and cellular biology - 1 Jan 2006

Dumortier Alexis, Jeannet Robin, Kirstetter Peggy, Kleinmann Eva, Sellars MacLean, dos Santos Nuno R, Thibault Christelle, Barths Jochen, Ghysdael Jacques, Punt Jennifer A, Kastner Philippe, Chan Susan

Abstract excerpt

The Ikaros transcription factor is both a key regulator of lymphocyte differentiation and a tumor suppressor in T lymphocytes. Mice carrying a hypomorphic mutation (Ik(L/L)) in the Ikaros gene all develop thymic lymphomas. Ik(L/L) tumors always exhibit strong activation of the Notch pathway, which is required for tumor cell proliferation in vitro. Notch activation occurs early in tumorigenesis and may precede...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16354692
DOI: 10.1128/MCB.26.1.209-220.2006
PMCID: PMC1317628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice.PMID 16354692Read ↗

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma.Semantic proximity Read ↗

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Ikaros Directly Represses the Notch Target Gene Hes1 in a Leukemia T Cell LineSemantic proximity Read ↗

The role of the Ikaros gene in lymphocyte development and homeostasis.Semantic proximity Read ↗

Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL.Semantic proximity Read ↗

Activated Notch counteracts Ikaros tumor suppression in mouse and human T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

Lack of Ikaros Deregulates Inflammatory Gene Programs in T CellsSemantic proximity Read ↗

Ikaros is critical for B cell differentiation and function.Semantic proximity Read ↗

Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation.Semantic proximity Read ↗

The ikaros gene is required for the development of all lymphoid lineagesSemantic proximity Read ↗

Zinc finger-mediated protein interactions modulate Ikaros activity, a molecular control of lymphocyte development.Semantic proximity Read ↗

Regulator of myeloid differentiation and function: The secret life of IkarosSemantic proximity Read ↗

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