Article
Filaggrin null mutations and childhood atopic eczema: a population-based case-control study.
The Journal of allergy and clinical immunology - 1 Apr 2008
Brown Sara J, Relton Caroline L, Liao Haihui, Zhao Yiwei, Sandilands Aileen, Wilson Ian J, Burn John, Reynolds Nick J, McLean W H Irwin, Cordell Heather J
Abstract excerpt
BACKGROUND: Null mutations within the filaggrin gene (FLG) are associated with moderate-to-severe atopic eczema; their role in mild-to-moderate eczema in the general population is unknown. OBJECTIVE: We sought to investigate the significance of 5 common FLG null mutations in childhood atopic eczema in an unselected population cohort. METHODS: Eight hundred eleven English children aged 7 to 9 years were screened...
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