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Article

Filaggrin null mutations are associated with increased asthma severity in children and young adults.

The Journal of allergy and clinical immunology - 1 Jul 2007

Palmer Colin N A, Ismail Tahmina, Lee Simon P, Terron-Kwiatkowski Ana, Zhao Yiwei, Liao Haihui, Smith Frances J D, McLean W H Irwin, Mukhopadhyay Somnath

Abstract excerpt

BACKGROUND: Filaggrin is a key protein involved in skin barrier function. Filaggrin (FLG) null mutations are important genetic predisposing factors for atopic disease. OBJECTIVE: To study the role of FLG null alleles in the clinical phenotype in children and young adults with asthma. METHODS: FLG mutations R501X and 2282del4 were assayed in 874 subjects 3 to 22 years old with asthma from Tayside. Lung function...

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Source

Identifiers

PMID: 17531295
DOI: 10.1016/j.jaci.2007.04.001

Genes

FLG
FEV

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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