Article
Chromosome 11q13.5 variant associated with childhood eczema: an effect supplementary to filaggrin mutations.
The Journal of allergy and clinical immunology - 1 Jan 2010
O'Regan Gráinne M, Campbell Linda E, Cordell Heather J, Irvine Alan D, McLean W H Irwin, Brown Sara J
Abstract excerpt
BACKGROUND: Atopic eczema is a common inflammatory skin disease with multifactorial etiology. The genetic basis is incompletely understood; however, loss of function mutations in the filaggrin gene (FLG) are the most significant and widely replicated genetic risk factor reported to date. The first genome-wide association study in atopic eczema recently identified 2 novel genetic variants in association with...
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