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Article

Filaggrin null mutations are associated with increased asthma exacerbations in children and young adults.

Allergy - 1 Sept 2008

Basu K, Palmer C N A, Lipworth B J, McLean W H Irwin, Terron-Kwiatkowski A, Zhao Y, Liao H, Smith F J D, Mitra A, Mukhopadhyay S

Abstract excerpt

BACKGROUND: Filaggrin (FLG) null mutations are important genetic predisposing factors for atopic asthma and have recently been shown to influence controller and reliever medication needs in asthmatic children. Our objective was to study the role of FLG null alleles in asthma exacerbations. METHODS: FLG mutations R501X and 2282del4 were assayed in 1135 individuals ranging from 3 to 22 years old with asthma from...

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Source

Identifiers

PMID: 18307574
DOI: 10.1111/j.1398-9995.2008.01660.x

Genes

FLG

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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