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Article

Filaggrin loss-of-function mutations as a predictor for atopic eczema, allergic sensitization and eczema-associated asthma in Polish children population.

Advances in clinical and experimental medicine : official organ Wroclaw Medical University - 1 Sept 2017

Dębińska Anna, Danielewicz Hanna, Drabik-Chamerska Anna, Kalita Danuta, Boznański Andrzej

Abstract excerpt

BACKGROUND: Loss-of-function mutations in the filaggrin (FLG) gene were identified as a major risk factor for atopic eczema. OBJECTIVES: The aim of the study was to investigate the importance of 4 common FLG null mutations in the susceptibility to atopic eczema and other allergic phenotypes in Polish children population. MATERIAL AND METHODS: The FLG mutations were determined in 158 children younger than 2 years...

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Identifiers

PMID: 29068602
DOI: 10.17219/acem/61430

Genes

FLG

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