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Article

Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood.

The Journal of investigative dermatology - 1 Mar 2007

Barker Jonathan N W N, Palmer Colin N A, Zhao Yiwei, Liao Haihui, Hull Peter R, Lee Simon P, Allen Michael H, Meggitt Simon J, Reynolds Nicholas J, Trembath Richard C, McLean W H Irwin

Abstract excerpt

Atopic dermatitis (AD) is a common disease with a complex etiology in childhood and adult life. A significant proportion of childhood AD is transient, but in many cases it persists into adulthood. We have recently shown that null mutations in the filaggrin gene (FLG) are an important predisposing...

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Source

Identifiers

PMID: 16990802
DOI: 10.1038/sj.jid.5700587

Genes

FLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16990802-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Null mutations in the filaggrin gene (FLG) determine major susceptibility to early-onset atopic dermatitis that persists into adulthood.PMID 16990802Read ↗

The persistence of atopic dermatitis and filaggrin (FLG) mutations in a US longitudinal cohort.Semantic proximity Read ↗

Filaggrin null mutations and childhood atopic eczema: a population-based case-control study.Semantic proximity Read ↗

The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study.Semantic proximity Read ↗

Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study.Semantic proximity Read ↗

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Prevalent and Low-Frequency Null Mutations in the Filaggrin Gene Are Associated with Early-Onset and Persistent Atopic EczemaSemantic proximity Read ↗

Filaggrin null mutations in childhood atopic dermatitis among the Chinese.Semantic proximity Read ↗

Prevalence of FLG loss‐of‐function mutations R501X, 2282del4, and R2447X in Spanish children with atopic dermatitisSemantic proximity Read ↗

Uncommon Filaggrin Variants Are Associated with Persistent Atopic Dermatitis in African Americans.Semantic proximity Read ↗

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Individuals who are homozygous for the 2282del4 and R501X filaggrin null mutations do not always develop dermatitis and complete long-term remission is possible.Semantic proximity Read ↗

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