Article
Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children.
The British journal of dermatology - 1 Oct 2009
Brown S J, Relton C L, Liao H, Zhao Y, Sandilands A, McLean W H I, Cordell H J, Reynolds N J
Abstract excerpt
BACKGROUND: Null mutations within the filaggrin gene (FLG) cause ichthyosis vulgaris and are associated with atopic eczema. However, the dermatological features of filaggrin haploinsufficiency have not been clearly defined. OBJECTIVES: This study investigated the genotype-phenotype association be...
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