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Article

Evolving insight into the role of mitochondrial DNA mutations in aging.

Experimental gerontology - 1 Jan 2008

Kujoth Gregory C, Prolla Tomas A

Abstract excerpt

Mitochondria have occupied a central place in theories on the underlying cellular mechanisms of eukaryotic aging for several decades and much debate has ensued regarding the role of oxidative stress and mitochondrial genomic damage in these processes. Mouse models with greatly enhanced mitochondrial mutagenesis have produced dramatic aging-like phenotypes but recent results have led some to reassess whether such...

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PMID: 18054193
DOI: 10.1016/j.exger.2007.09.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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