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Article

DJ-1 modulates UV-induced oxidative stress signaling through the suppression of MEKK1 and cell death.

Cell death and differentiation - 1 Jun 2008

Mo J-S, Kim M-Y, Ann E-J, Hong J-A, Park H-S

Abstract excerpt

DJ-1 is a multifunctional protein that performs functions in transcriptional regulation and oxidative stress, and the loss of its function is believed to result in the onset of Parkinson's disease (PD). In this study, we report that DJ-1 protects against UV-induced cell death through the suppression of the JNK1 signaling pathway. The results of both binding and kinase studies have revealed that MEKK1 is the...

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Source

Identifiers

PMID: 18309325
DOI: 10.1038/cdd.2008.26

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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