Article
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.
Biochemical and biophysical research communications - 26 Dec 2003
Yokota Takanori, Sugawara Kanako, Ito Kaoru, Takahashi Ryosuke, Ariga Hiroyoshi, Mizusawa Hidehiro
Abstract excerpt
Mutations in DJ-1 gene have been linked to autosomal recessive early onset parkinsonism (AR-EOP). Although the mechanism of neuronal cell death due to DJ-1 mutation has not been fully elucidated, loss of DJ-1 function was considered to cause the phenotype. Here, we demonstrated that the down regulation of endogenous DJ-1 of the neuronal cell line by siRNA enhanced the cell death which was induced by oxidative...
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