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Article

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.

Molecular neurodegeneration - 14 Aug 2012

Ren Haigang, Fu Kai, Mu Chenchen, Zhen Xuechu, Wang Guanghui

Abstract excerpt

BACKGROUND: Mutations or deletions in DJ-1/PARK7 gene are causative for recessive forms of early onset Parkinson's disease (PD). Wild-type DJ-1 has cytoprotective roles against cell death through multiple pathways. The most commonly studied mutant DJ-1(L166P) shifts its subcellular distribution to mitochondria and renders cells more susceptible to cell death under stress stimuli. We previously reported that...

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Identifiers

PMID: 22892098
DOI: 10.1186/1750-1326-7-40
PMCID: PMC3479024

Genes

PARK7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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