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Article

Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2005

Junn Eunsung, Taniguchi Hiroyuki, Jeong Byeong Seon, Zhao Xin, Ichijo Hidenori, Mouradian M Maral

Abstract excerpt

Investigations into the cellular and molecular biology of genes that cause inherited forms of Parkinson's disease, as well as the downstream pathways that they trigger, shed considerable light on our understanding the fundamental determinants of life and death in dopaminergic neurons. Homozygous deletion or missense mutation in DJ-1 results in autosomal recessively inherited Parkinson's disease, suggesting that...

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Identifiers

PMID: 15983381
DOI: 10.1073/pnas.0409635102
PMCID: PMC1172235

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death.PMID 15983381Read ↗

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Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO.Semantic proximity Read ↗

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.Semantic proximity Read ↗

Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition.Semantic proximity Read ↗

Oxidizable residues mediating protein stability and cytoprotective interaction of DJ-1 with apoptosis signal-regulating kinase 1.Semantic proximity Read ↗

Modulation of signaling pathways by DJ-1: An updated overviewSemantic proximity Read ↗

DJ-1 is indispensable for the S-nitrosylation of Parkin, which maintains function of mitochondriaSemantic proximity Read ↗

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The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis.Semantic proximity Read ↗

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1Semantic proximity Read ↗

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