Article
Involvement of ERK1/2 signaling pathway in DJ-1-induced neuroprotection against oxidative stress.
Biochemical and biophysical research communications - 12 Jun 2009
Gu Li, Cui Tao, Fan Chunxiang, Zhao Huanying, Zhao Chunli, Lu Lingling, Yang Hui
Abstract excerpt
Parkinson's disease (PD) is a progressive neurodegenerative disorder. Although the precise mechanism remains unclear, mounting evidence suggests that oxidative stress plays an important role in the pathogenesis of PD. DJ-1 gene is associated with oxidative stress and mutations in DJ-1 are involved in an autosomal recessive, early onset familial form of PD. The ERK1/2 signaling pathway contributes to...
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