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Article

dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster.

Cell cycle (Georgetown, Tex.) - 15 Oct 2012

Stefanatos Rhoda, Sriram Ashwin, Kiviranta Essi, Mohan Aravind, Ayala Victoria, Jacobs Howard T, Pamplona Reinald, Sanz Alberto

Abstract excerpt

DJ-1 (or PARK-7) is a multifunctional protein implicated in numerous pathologies including cancer, sterility and Parkinson disease (PD). The popular genetic model Drosophila melanogaster has two orthologs, dj-1: α and β. Dysfunction of dj-1β strongly impairs fly mobility in an age-dependent manner. In this study, we analyze in detail the molecular mechanism underlying the dj-1β mutant phenotype. Mitochondrial...

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Identifiers

PMID: 22983063
DOI: 10.4161/cc.22073
PMCID: PMC3495829

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