Article
Drosophila DJ-1 decreases neural sensitivity to stress by negatively regulating Daxx-like protein through dFOXO.
PLoS genetics - 1 Apr 2013
Hwang Soojin, Song Saera, Hong Yoon Ki, Choi Gahee, Suh Yoon Seok, Han Seung Yeop, Lee Minjung, Park Seung Hwan, Lee Jang Ho, Lee Soojin, Bang Se Min, Jeong Yuji, Chung Won-Ju, Lee Im-Soon, Jeong Gilsang, Chung Jongkyeong, Cho Kyoung Sang
Abstract excerpt
DJ-1, a Parkinson's disease (PD)-associated gene, has been shown to protect against oxidative stress in Drosophila. However, the molecular mechanism underlying oxidative stress-induced phenotypes, including apoptosis, locomotive defects, and lethality, in DJ-1-deficient flies is not fully understood. Here we showed that Daxx-like protein (DLP), a Drosophila homologue of the mammalian Death domain-associated...
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