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Article

Nuclear DJ-1 Regulates DNA Damage Repair via the Regulation of PARP1 Activity.

International journal of molecular sciences - 12 May 2023

Wang Zhong-Xuan, Liu Yi, Li Yao-Lin, Wei Qiao, Lin Rong-Rong, Kang Ruiqing, Ruan Yang, Lin Zhi-Hao, Xue Nai-Jia, Zhang Bao-Rong, Pu Jia-Li

Abstract excerpt

DNA damage and defective DNA repair are extensively linked to neurodegeneration in Parkinson's disease (PD), but the underlying molecular mechanisms remain poorly understood. Here, we determined that the PD-associated protein DJ-1 plays an essential role in modulating DNA double-strand break (DSB) repair. Specifically, DJ-1 is a DNA damage response (DDR) protein that can be recruited to DNA damage sites, where it...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 37239999
DOI: 10.3390/ijms24108651
PMCID: PMC10218208

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