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Article

Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress.

Current biology : CB - 6 Sept 2005

Menzies Fiona M, Yenisetti Sarat C, Min Kyung-Tai

Abstract excerpt

The loss of dopaminergic neurons in the substantia nigra is the pathological hallmark of Parkinson's disease (PD). While the etiology of sporadic PD remains elusive, an inherited form of early-onset familial PD is linked to mutations of DJ-1. To understand the biological function of DJ-1 and its relevance to the pathogenesis of PD, we investigated the function of DJ-1 using Drosophila. Drosophila possesses two...

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Identifiers

PMID: 16139214
DOI: 10.1016/j.cub.2005.07.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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