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Article

Apoptosis induced by cytoskeletal disruption requires distinct domains of MEKK1.

PloS one - 25 Feb 2011

Tricker Erin, Arvand Afsane, Kwan Raymond, Chen Gordon Y, Gallagher Ewen, Cheng Genhong

Abstract excerpt

MEKK1 is a mitogen-activated protein kinase kinase kinase (MAP3K) that activates the MAPK JNK and is required for microtubule inhibitor-induced apoptosis in B cells. Here, we find that apoptosis induced by actin disruption via cytochalasin D and by the protein phosphatase 1/2A inhibitor okadaic acid also requires MEKK1 activation. To elucidate the functional requirements for activation of the MEKK1-dependent...

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Source

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Identifiers

PMID: 21364884
DOI: 10.1371/journal.pone.0017310
PMCID: PMC3045432

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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