Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimation of significance thresholds for genomewide association scans.

Genetic epidemiology - 1 Apr 2008

Dudbridge Frank, Gusnanto Arief

Abstract excerpt

The question of what significance threshold is appropriate for genomewide association studies is somewhat unresolved. Previous theoretical suggestions have yet to be validated in practice, whereas permutation testing does not resolve a discrepancy between the genomewide multiplicity of the experiment and the subset of markers actually tested. We used genotypes from the Wellcome Trust Case-Control Consortium to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Genetic Markers
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Human

Share to Genotype

Share to United Kingdom

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 18300295
DOI: 10.1002/gepi.20297
PMCID: PMC2573032

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimation of significance thresholds for genomewide association scans.PMID 18300295Read ↗

Eigenvalue significance testing for genetic association.Semantic proximity Read ↗

Genome-wide significance for dense SNP and resequencing data.Semantic proximity Read ↗

Kernel-smoothed permutation for extreme P-value estimation in genetic association studies.Semantic proximity Read ↗

Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies.Semantic proximity Read ↗

Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies.Semantic proximity Read ↗

Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project.Semantic proximity Read ↗

P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies.Semantic proximity Read ↗

What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations.Semantic proximity Read ↗

Hypothesis testing at the extremes: fast and robust association for high-throughput data.Semantic proximity Read ↗

Avoiding the high Bonferroni penalty in genome-wide association studies.Semantic proximity Read ↗

Power analysis for genome-wide association studies.Semantic proximity Read ↗

Dimensionality of genomic information and its impact on genome-wide associations and variant selection for genomic prediction: a simulation study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.