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Article

P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies.

Journal of clinical epidemiology - 1 Apr 2015

Jannot Anne-Sophie, Ehret Georg, Perneger Thomas

Abstract excerpt

OBJECTIVES: In genome-wide association studies (GWASs), the practice regarding the choice of thresholds of significance and of thresholds used to include single nucleotide polymorphisms (SNPs) in a further validation stage is not well known. Here, we performed a systematic analysis of all GWASs published in two recent but nonconsecutive periods to assess whether any consensus was emerging regarding the choice of...

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PMID: 25666886
DOI: 10.1016/j.jclinepi.2015.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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