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Article

Kernel-smoothed permutation for extreme P-value estimation in genetic association studies.

Genetics - 6 Jul 2026

Bian Jiayi, Wu Jingjing, Ethan MacDonald M, Wu Lang, Long Quan, Li Caifeng

Abstract excerpt

In genetic association studies, permutation tests serve as a cornerstone to estimate P-values. This is because researchers may design new test statistics without a known closed-form distribution, or the assumption of a well-established test may not hold. However, permutation tests require a vast number of permutations, which is proportional to the magnitude of the actual P-values. When it comes to genome-wide...

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PMID: 42114112
DOI: 10.1093/genetics/iyag119
PMCID: PMC13334087

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