Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies.

BMC genomics - 31 Oct 2008

Duggal Priya, Gillanders Elizabeth M, Holmes Taura N, Bailey-Wilson Joan E

Abstract excerpt

BACKGROUND: By assaying hundreds of thousands of single nucleotide polymorphisms, genome wide association studies (GWAS) allow for a powerful, unbiased review of the entire genome to localize common genetic variants that influence health and disease. Although it is widely recognized that some correction for multiple testing is necessary, in order to control the family-wide Type 1 Error in genetic association...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms
Share to BRCA gene mutations in cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Associations and Epidemiology

Share to Genome, Human

Share to Genome-Wide Association Study

Share to Hemoglobinopathies and Related Disorders

Share to Linkage Disequilibrium

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 18976480
DOI: 10.1186/1471-2164-9-516
PMCID: PMC2621212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Establishing an adjusted p-value threshold to control the family-wide type 1 error in genome wide association studies.PMID 18976480Read ↗

Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets.Semantic proximity Read ↗

Genomic screening and replication using the same data set in family-based association testing.Semantic proximity Read ↗

On multiple-testing correction in genome-wide association studies.Semantic proximity Read ↗

Estimation of the multiple testing burden for genomewide association studies of nearly all common variants.Semantic proximity Read ↗

Association testing strategy for data from dense marker panels.Semantic proximity Read ↗

Correction for multiple testing in a gene region.Semantic proximity Read ↗

Significance levels in genome-wide interaction analysis (GWIA).Semantic proximity Read ↗

Beyond 5×10⁻⁸: MAF-Specific Significance Thresholds for Genome-Wide Association Studies in three major populationsSemantic proximity Read ↗

Calibrating genome wide significance by minor allele frequency across three major populations.Semantic proximity Read ↗

Factors affecting statistical power in the detection of genetic association.Semantic proximity Read ↗

Evaluating and improving power in whole-genome association studies using fixed marker sets.Semantic proximity Read ↗

From single-SNP to wide-locus: genome-wide association studies identifying functionally related genes and intragenic regions in small sample studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.