Article
Avoiding the high Bonferroni penalty in genome-wide association studies.
Genetic epidemiology - 1 Jan 2010
Gao Xiaoyi, Becker Lewis C, Becker Diane M, Starmer Joshua D, Province Michael A
Abstract excerpt
A major challenge in genome-wide association studies (GWASs) is to derive the multiple testing threshold when hypothesis tests are conducted using a large number of single nucleotide polymorphisms. Permutation tests are considered the gold standard in multiple testing adjustment in genetic association studies. However, it is computationally intensive, especially for GWASs, and can be impractical if a large number...
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