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Article

Eigenvalue significance testing for genetic association.

Biometrics - 1 Jun 2018

Zhou Yi-Hui, Marron J S, Wright Fred A

Abstract excerpt

Genotype eigenvectors are widely used as covariates for control of spurious stratification in genetic association. Significance testing for the accompanying eigenvalues has typically been based on a standard Tracy-Widom limiting distribution for the largest eigenvalue, derived under white-noise assumptions. It is known that even modest local correlation among markers inflates the largest eigenvalues, even in the...

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PMID: 28853138
DOI: 10.1111/biom.12767
PMCID: PMC6069632

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