Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations.

International journal of epidemiology - 1 Feb 2012

Panagiotou Orestis A, Ioannidis John P A

Abstract excerpt

BACKGROUND: Robust replication is a sine qua non for the rigorous documentation of proposed associations in the genome-wide association (GWA) setting. Currently, associations of common variants reaching P ≤ 5 × 10(-8) are considered replicated. However, there is some ambiguity about the most suitable threshold for claiming genome-wide significance. METHODS: We defined as 'borderline' associations those with P > 5...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Association Studies
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Reference Standards

Source

Identifiers

PMID: 22253303
DOI: 10.1093/ije/dyr178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations.PMID 22253303Read ↗

Is replication the gold standard for validating genome-wide association findings?Semantic proximity Read ↗

P < 5 × 10(-8) has emerged as a standard of statistical significance for genome-wide association studies.Semantic proximity Read ↗

Non-replication and inconsistency in the genome-wide association setting.Semantic proximity Read ↗

Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies.Semantic proximity Read ↗

Required sample size and nonreplicability thresholds for heterogeneous genetic associations.Semantic proximity Read ↗

The Phenotype-Genotype Reference Map: Improving biobank data science through replicationSemantic proximity Read ↗

Reproducibility in the UK biobank of genome-wide significant signals discovered in earlier genome-wide association studies.Semantic proximity Read ↗

Replication of Known and Identification of Novel Associations in Biobank-Scale Datasets: A Survey Using UK Biobank and FinnGen.Semantic proximity Read ↗

P-values in genomics: apparent precision masks high uncertainty.Semantic proximity Read ↗

Statistical Correction of the Winner’s Curse Explains Replication Variability in Quantitative Trait Genome-Wide Association StudiesSemantic proximity Read ↗

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease.Semantic proximity Read ↗

Jointly determining significance levels of primary and replication studies by controlling the false discovery rate in two-stage genome-wide association studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.