Article
Timing of deletion of autoreactive V beta 6+ cells and down-modulation of either CD4 or CD8 on phenotypically distinct CD4+8+ subsets of thymocytes expressing intermediate or high levels of T cell receptor.
International immunology - 1 Mar 1991
Hugo P, Boyd R L, Waanders G A, Petrie H T, Scollay R
Abstract excerpt
In this paper we describe a differentiation sequence amongst adult murine thymocytes which goes from CD4+8+3lo(low) to CD4+8+3int(intermediate) to CD4+8+3hi(high) and then to mature single positive CD3hi thymocytes. Phenotypic characterization of CD4+8+3int/hi cells for a number of other surface...
Topics
- Animals
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD3 Complex
- CD4 Antigens
- CD8 Antigens
- Cell Survival
- Down-Regulation
- Mice
- Mice, Inbred Strains
- Phenotype
- Receptors, Antigen, T-Cell
- T-Lymphocyte Subsets