Article
Intrathymic activation events and the generation of IL-4 producer CD4+8- thymocytes.
Seminars in immunology - 1 Jun 1992
Bendelac A
Abstract excerpt
The generation of mouse CD4+8- thymocytes appears to involve an activation process. CD69, an early activation marker, is first expressed on 3% of TCRlo/med double-positive thymocytes and peaks (70-90%) at the HSAhi TCRmed CD4+8lo and the HSAhi TCRhi CD4+8- stages, before being downmodulated. CD44...
Topics
- Animals
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- Autoimmunity
- CD4-Positive T-Lymphocytes
- Cell Differentiation
- Gene Expression
- Interleukin-2
- Interleukin-4
- Lectins, C-Type
- Lymphocyte Activation
- Mice
- Phenotype
- Receptors, Antigen, T-Cell
- Receptors, Lymphocyte Homing
- Thymus Gland