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Article

Intrathymic activation events and the generation of IL-4 producer CD4+8- thymocytes.

Seminars in immunology - 1 Jun 1992

Bendelac A

Abstract excerpt

The generation of mouse CD4+8- thymocytes appears to involve an activation process. CD69, an early activation marker, is first expressed on 3% of TCRlo/med double-positive thymocytes and peaks (70-90%) at the HSAhi TCRmed CD4+8lo and the HSAhi TCRhi CD4+8- stages, before being downmodulated. CD44, a marker of a later stage of activation is selectively expressed at the HSAlo CD4+8- stage. Functional changes...

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PMID: 1352709

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