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Article

The late stage of T cell development within mouse thymus.

Cellular & molecular immunology - 1 Feb 2004

Chen Weifeng

Abstract excerpt

After positive selection and lineage commitment, the TCR alphabeta+ CD4/CD8 SP medullary thymocytes migrate into and reside in thymic medulla, where they undergo an ordered program of late stage of T cell functional maturation and negative selection to delete self-reactive clones by apoptosis. Accomplishment of this final differentiation pathway, a physiological T cell repertoire is formed: T cells acquire...

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PMID: 16212915

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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