Article
RelB reduces thymocyte apoptosis and regulates terminal thymocyte maturation.
European journal of immunology - 1 Jan 2002
Guerin Sandrine, Baron Marie-Laurence, Valero René, Herrant Magali, Auberger Patrick, Naquet Philippe
Abstract excerpt
Thymocyte maturation is controlled by successive developmental checkpoints connected to the acquisition of a functional T cell receptor (TCR). During thymocyte selection, engagement of the TCR regulates the fine balance between death and survival signals. At the final stages of single-positive (SP) thymocyte maturation, the coupling of the TCR changes from death- to proliferation-inducing signals, a competence...
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