Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage.

Molecular and cellular biology - 1 Apr 2008

Jha Sudhakar, Shibata Etsuko, Dutta Anindya

Abstract excerpt

The role of chromatin-remodeling factors in transcription is well established, but the link between chromatin-remodeling complexes and DNA repair remains unexplored. Human Rvb1 and Rvb2 are highly conserved AAA(+) ATP binding proteins that are part of various chromatin-remodeling complexes, such as Ino80, SNF2-related CBP activator protein (SRCAP), and Tip60/NuA4 complexes, but their molecular function is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to ATPases Associated with Diverse Cellular Activities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to DNA Helicases

Share to Histone Acetyltransferases

Share to Histones

Share to Phosphatidylinositol 3-Kinases

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 18285460
DOI: 10.1128/MCB.01983-07
PMCID: PMC2293106

Genes

H2AX
SRCAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage.PMID 18285460Read ↗

The Human RVB Complex Is Required for Efficient Transcription of Type I Interferon-Stimulated GenesSemantic proximity Read ↗

The multitalented TIP60 chromatin remodeling complex: wearing many hats in epigenetic regulation, cell division and diseasesSemantic proximity Read ↗

The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cellsSemantic proximity Read ↗

Activation of a Tip60/E2F1/ERCC1 network in human lung adenocarcinoma cells exposed to cisplatinSemantic proximity Read ↗

Concomitant acetylation and loading of H2A.Z by NuA4/TIP60 regulate target gene transcriptionSemantic proximity Read ↗

Proteotoxic stress-induced Nrf1 transcriptional program requires a functional TIP60 complexSemantic proximity Read ↗

Post-translational modifications of epigenetic modifier TIP60: their role in cellular functions and cancerSemantic proximity Read ↗

Tip60 acetyltransferase activity is controlled by phosphorylation.Semantic proximity Read ↗

Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes.Semantic proximity Read ↗

Chromatin remodeling and the maintenance of genome integrity.Semantic proximity Read ↗

EP400NL is required for cMyc-mediated PD-L1 gene activation by forming a transcriptional coactivator complexSemantic proximity Read ↗

The TIP60 Complex Is a Conserved Coactivator of HIF1ASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.