Article

EP400NL is required for cMyc-mediated PD-L1 gene activation by forming a transcriptional coactivator complex

2021-05-31

Abstract excerpt

<h4>ABSTRACT</h4> EP400 is an ATP-dependent chromatin remodeling enzyme that has been implicated in DNA double-strand break repair and transcription regulation including Myc-dependent gene expression. We previously showed that the N-terminal domain of EP400 increases the efficacy of chemotherapeutic drugs against cancer cells. As the EP400 N-terminal-Like (EP400NL) gene resides next to the EP400 gene locus prompt...

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Literature Corpus work: 620e95ee-4592-5058-bb61-d365116c28a5
DOI: 10.1101/2021.05.30.446361

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