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The Human RVB Complex Is Required for Efficient Transcription of Type I Interferon-Stimulated Genes

23 Jul 2013

Abstract excerpt

Type I interferons (IFNs) stimulate transcription through a latent heterotrimeric transcription factor composed of tyrosine-phosphorylated STAT1 and STAT2 and the DNA binding partner IRF9, with STAT2 contributing a critical transactivation domain. Human RVB1 and RVB2, which are highly conserved AAA(+) ATP binding proteins contained in chromatin-remodeling complexes such as Ino80, SNF2-related CBP activator...

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PMID: 23878400
DOI: 10.1128/mcb.01562-12

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