Article
Rvb1p and Rvb2p are essential components of a chromatin remodeling complex that regulates transcription of over 5% of yeast genes.
The Journal of biological chemistry - 11 May 2001
Jónsson Z O, Dhar S K, Narlikar G J, Auty R, Wagle N, Pellman D, Pratt R E, Kingston R, Dutta A
Abstract excerpt
Eukaryotic Rvb1p and Rvb2p are two highly conserved proteins related to the helicase subset of the AAA+ family of ATPases. Conditional mutants in both genes show rapid changes in the transcription of over 5% of yeast genes, with a similar number of genes being repressed and activated. Both Rvb1p and Rvb2p are required for maintaining the induced state of many inducible promoters. ATP binding and hydrolysis by...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Chromatin
- DNA Helicases
- Enzymes
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genome, Fungal
- Genotype
- Oligonucleotide Array Sequence Analysis
- RNA Helicases
- Recombinant Fusion Proteins