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Article

Tip60 acetyltransferase activity is controlled by phosphorylation.

The Journal of biological chemistry - 14 Feb 2003

Lemercier Claudie, Legube Gaëlle, Caron Cécile, Louwagie Mathilde, Garin Jérôme, Trouche Didier, Khochbin Saadi

Abstract excerpt

Here we show that the phosphorylation of histone acetyltransferase Tip60, a target of human immunodeficiency virus, type 1-encoded transactivator Tat, plays a crucial role in the control of its catalytic activity. Baculovirus-based expression and purification of Tip60 combined with mass spectrome...

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Identifiers

PMID: 12468530
DOI: 10.1074/jbc.M211811200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12468530-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Tip60 acetyltransferase activity is controlled by phosphorylation.PMID 12468530Read ↗

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Systematic Analysis of the Functions of Lysine Acetylation in the Regulation of Tat Activity.Semantic proximity Read ↗

Human Rvb1/Tip49 is required for the histone acetyltransferase activity of Tip60/NuA4 and for the downregulation of phosphorylation on H2AX after DNA damage.Semantic proximity Read ↗

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