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Post-translational modifications of epigenetic modifier TIP60: their role in cellular functions and cancer

4 Apr 2025

Abstract excerpt

TIP60 is a crucial lysine acetyltransferase protein that catalyzes the acetylation of histone and non-histone proteins. This enzyme plays a crucial role in maintaining genomic integrity, by participating in DNA damage repair, ensuring accurate chromosomal segregation, and regulating a myriad of cellular processes such as apoptosis, autophagy, and wound-induced cell migration. One of the primary mechanisms through...

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PMID: 40186325
DOI: 10.1186/s13072-025-00572-y

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