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Article

The TIP60 Complex Is a Conserved Coactivator of HIF1A

1 Jun 2016

Abstract excerpt

Hypoxia-inducible factors (HIFs) are critical regulators of the cellular response to hypoxia. Despite their established roles in normal physiology and numerous pathologies, the molecular mechanisms by which they control gene expression remain poorly understood. We report here a conserved role for the TIP60 complex as a HIF1 transcriptional cofactor in Drosophila and human cells. TIP60 (KAT5) is required for...

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Identifiers

PMID: 27320910
DOI: 10.1016/j.celrep.2016.05.082

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