Article
Chromatin remodeling and the maintenance of genome integrity.
Biochimica et biophysica acta - 15 Mar 2004
Allard Stéphane, Masson Jean-Yves, Côté Jacques
Abstract excerpt
DNA damage of any type is threatening for a cell. If lesions are left unrepaired, genomic instability can arise, faithful transmission of genetic information is greatly compromised eventually leading the cell to undergo apoptosis or carcinogenesis. In order to access/detect and repair these damages, repair factors must circumvent the natural repressive barrier of chromatin. This review will present recent...
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