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The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells

18 Jun 2022

Abstract excerpt

Maintenance of replication fork stability is essential for genome preservation. Stalled replication forks can be reversed by translocases such as SMARCAL1, and unless protected through the activity of the BRCA pathway, are subsequently subjected to nucleolytic degradation. The ATM and ATR kinases are master regulators of the DNA damage response. ATM activation upon DNA damage is mediated by the acetyltransferase...

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PMID: 35717336
DOI: 10.1038/s41389-022-00410-w

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