Article

Proteotoxic stress-induced Nrf1 transcriptional program requires a functional TIP60 complex

2018-10-16

Abstract excerpt

<h4>ABSTRACT</h4> In response to inhibition of the cellular proteasome, the transcription factor Nrf1 (also called NFE2L1) induces transcription of proteasome subunit genes resulting in the restoration of proteasome activity and thus enabling the cells to mitigate the proteotoxic stress. To identify novel regulators of Nrf1, we performed an RNA interference screen and discovered that the AAA+ ATPase RUVBL1 is nec...

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Literature Corpus work: a1683b8d-e415-5285-8f44-540bc90e9e0a
DOI: 10.1101/443937

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