Article
Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers.
Carcinogenesis - 1 Apr 2008
Cybulski Cezary, Masojc Bartlomiej, Oszutowska Dorota, Jaworowska Ewa, Grodzki Tomasz, Waloszczyk Piotr, Serwatowski Piotr, Pankowski Juliusz, Huzarski Tomasz, Byrski Tomasz, Górski Bohdan, Jakubowska Anna, Debniak Tadeusz, Wokolorczyk Dominika, Gronwald Jacek, Tarnowska Czeslawa, Serrano-Fernández Pablo, Lubinski Jan, Narod Steven A
Abstract excerpt
Mutations in the CHEK2 gene have been associated with increased risks of breast, prostate and colon cancer. In contrast, a previous report suggests that individuals with the I157T missense variant of the CHEK2 gene might be at decreased risk of lung cancer and upper aero-digestive cancers. To confirm this hypothesis, we genotyped 895 cases of lung cancer, 430 cases of laryngeal cancer and 6391 controls from...
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