Article
Alterations of CHEK2 forkhead-associated domain increase the risk of Hodgkin lymphoma.
Neoplasma - 1 Jan 2011
Havranek O, Spacek M, Hubacek P, Mocikova H, Markova J, Trneny M, Kleibl Z
Abstract excerpt
Checkpoint kinase 2 gene (CHEK2) codes for an important mediator of DNA damage response pathway. Mutations in the CHEK2 gene increase the risk of several cancer types, however, their role in Hodgkin lymphoma (HL) has not been studied so far. The most frequent CHEK2 alterations (including c.470T>C; p.I157T) cluster into the forkhead-associated (FHA) domain-coding region of the CHEK2 gene. We performed mutation...
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