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Article

Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations.

Journal of medical genetics - 1 Feb 2009

Cybulski C, Górski B, Huzarski T, Byrski T, Gronwald J, Debniak T, Wokolorczyk D, Jakubowska A, Serrano-Fernández P, Dork T, Narod S A, Lubinski J

Abstract excerpt

BACKGROUND: Carriers of heterozygous mutations in CHEK2 or BRCA1 are at increased risk of breast cancer. These mutations are rare and a very small number of women in a population will carry two mutations. However, it is of interest to estimate the breast cancer risks associated with carrying two...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18930998
DOI: 10.1136/jmg.2008.061697

Genes

CHEK2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18930998-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Effect of CHEK2 missense variant I157T on the risk of breast cancer in carriers of other CHEK2 or BRCA1 mutations.PMID 18930998Read ↗

The CHEK2 I157T variant and breast cancer susceptibility: a systematic review and meta-analysis.Semantic proximity Read ↗

Germline CHEK2 mutations and colorectal cancer risk: different effects of a missense and truncating mutations?Semantic proximity Read ↗

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CHEK2 is a multiorgan cancer susceptibility gene.Semantic proximity Read ↗

Breast cancer predisposing alleles in Poland.Semantic proximity Read ↗

Patient survival and tumor characteristics associated with CHEK2:p.I157T – findings from the Breast Cancer Association ConsortiumSemantic proximity Read ↗

Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers.Semantic proximity Read ↗

The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

Current perspectives on CHEK2 mutations in breast cancerSemantic proximity Read ↗

Pathology of breast cancer in women with constitutional CHEK2 mutations.Semantic proximity Read ↗

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