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Article

Variant allele of CHEK2 is associated with a decreased risk of esophageal cancer lymph node metastasis in a Chinese population.

Molecular biology reports - 1 May 2012

Gu Haiyong, Qiu Wanshan, Wan Ying, Ding Guowen, Tang Weifeng, Liu Chao, Shi Yijun, Chen Yijang, Chen Suocheng

Abstract excerpt

Growing evidence suggests that the checkpoint kinase 2 (CHEK2) signaling pathway occupies a central position in the signaling networks of DNA-damage signaling. Many functional and molecular epidemiological studies have evaluated the association between genetic variants of CHEK2 and various cancer...

Read the complete abstract on PubMed

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Source

Identifiers

PMID: 22201027
DOI: 10.1007/s11033-011-1410-1

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22201027-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Variant allele of CHEK2 is associated with a decreased risk of esophageal cancer lymph node metastasis in a Chinese population.PMID 22201027Read ↗

Associations between mutations of the cell cycle checkpoint kinase 2 gene and gastric carcinogenesis.Semantic proximity Read ↗

A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.Semantic proximity Read ↗

Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population.Semantic proximity Read ↗

Mutations of the CHEK2 gene in patients with cancer and their presence in the Latin American populationSemantic proximity Read ↗

The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers.Semantic proximity Read ↗

PTPN13 rs989902 and CHEK2 rs738722 are associated with esophageal cancer.Semantic proximity Read ↗

A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk.Semantic proximity Read ↗

Prognostic Significance of CHEK2 Mutation in Progression of Breast CancerSemantic proximity Read ↗

Status of CHEK2 and p53 in patients with early‑onset and conventional gastric cancerSemantic proximity Read ↗

Genetic variants in CHEK1 gene are associated with the prognosis of thoracic esophageal squamous cell carcinoma patients treated with radical resection.Semantic proximity Read ↗

Association of CHEK2 polymorphisms with the efficacy of platinum-based chemotherapy for advanced non-small-cell lung cancer in Chinese never-smoking womenSemantic proximity Read ↗

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