Article
The risk of gastric cancer in carriers of CHEK2 mutations.
Familial cancer - 1 Sept 2013
Teodorczyk Urszula, Cybulski Cezary, Wokołorczyk Dominika, Jakubowska Anna, Starzyńska Teresa, Lawniczak Małgorzata, Domagała Paweł, Ferenc Katarzyna, Marlicz Krzysztof, Banaszkiewicz Zbigniew, Wiśniowski Rafał, Narod Steven A, Lubiński Jan
Abstract excerpt
CHEK2 is a tumor suppressor gene whose functions are central to the induction of cell cycle arrest and apoptosis following DNA damage. Mutations in CHEK2 have been associated with cancers at many sites, including breast and prostate cancers, but the relationship between CHEK2 and gastric cancer has not been extensively studied. In Poland, there are four known founder alleles of CHEK2; three alleles are protein...
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