Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.

doi:10.1093/hmg/ddm127

Article

Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.

Human molecular genetics - 1 Aug 2007

Brennan Paul, McKay James, Moore Lee, Zaridze David, Mukeria Anush, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Chow Wong-Ho, Rothman Nathanial, Chabrier Amelie, Gaborieau Valerie, Odefrey Fabrice, Southey Melissa, Hashibe Mia, Hall Janet, Boffetta Paolo, Peto Julian, Peto Richard, Hung Rayjean J

Abstract excerpt

CHEK2 is a key cell cycle control gene encoding a pluripotent kinase that can cause arrest or apoptosis in response to unrepaired DNA damage. We report a large case-control study of a non-functional variant that had previously been expected to increase cancer rates. Four thousand and fifteen canc...

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Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.

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