A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.

doi:10.1093/carcin/bgq089

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Article

A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.

Carcinogenesis - 1 Jul 2010

Zhang Shuyu, Lu Juan, Zhao Xueying, Wu Wenting, Wang Huibo, Lu Jun, Wu Qihan, Chen Xin, Fan Weiwei, Chen Hongyan, Wang Feng, Hu Zhibin, Jin Li, Wei Qingyi, Shen Hongbing, Huang Wei, Lu Daru

Abstract excerpt

Checkpoint kinase (CHEK) 2, a tumor suppressor gene, plays an essential role in the DNA damage checkpoint response cascade. We first investigated two polymorphisms in the proximal promoter of the CHEK2 gene and evaluated their associations with the risk of lung cancer in a case-control study using 500 incident lung cancer cases and 517 cancer-free controls. We found that CHEK2 rs2236141 -48 G > A was...

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PMID: 20462940
DOI: 10.1093/carcin/bgq089

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CHEK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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