Article
ESC, ESCL and their roles in Polycomb Group mechanisms.
Mechanisms of development - 1 Jan 2000
Ohno Katsuhito, McCabe Donna, Czermin Birgit, Imhof Axel, Pirrotta Vincenzo
Abstract excerpt
The Drosophila esc gene is a Polycomb Group (PcG) gene whose product is essential for histone H3 K27 methylation and PcG silencing yet genetic analysis indicated that its product was needed only in the very early embryo. We know now that escl, a close homologue of esc exists in the Drosophila genome. In contrast with earlier studies, we find that both esc and escl are expressed at all stages of development. We...
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