Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse homolog of the Drosophila Pc-G gene esc exerts a dominant negative effect in Drosophila.

Genesis (New York, N.Y. : 2000) - 1 Jan 2000

Wang J, Tie F, Jane E, Schumacher A, Harte P J, Magnuson T

Abstract excerpt

The Polycomb group genes are involved in maintaining long term transcriptional repression of the homeotic genes in both Drosophila and mammals. The mouse eed locus encodes the highly conserved ortholog of the Drosophila ESC protein. To test the functional conservation between the two genes, eed was introduced into the fly to determine whether it could rescue the esc mutant phenotype. eed exerted a dominant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extremities
Share to Genes, Lethal
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Insect Proteins

Share to Macromolecular Substances

Share to Polycomb Repressive Complex 1

Share to Polycomb Repressive Complex 2

Source

Identifiers

PMID: 10660674
DOI: 10.1002/(sici)1526-968x(200001)26:1<67::aid-gene9>3.3.co;2-u

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse homolog of the Drosophila Pc-G gene esc exerts a dominant negative effect in Drosophila.PMID 10660674Read ↗

The Drosophila extra sex combs protein contains WD motifs essential for its function as a repressor of homeotic genes.Semantic proximity Read ↗

Polycomb group regulation of Hox gene expression in C. elegans.Semantic proximity Read ↗

The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.Semantic proximity Read ↗

Positional cloning of a global regulator of anterior-posterior patterning in mice.Semantic proximity Read ↗

ESC, ESCL and their roles in Polycomb Group mechanisms.Semantic proximity Read ↗

Interactions of polyhomeotic with Polycomb group genes of Drosophila melanogaster.Semantic proximity Read ↗

The ESC-E(Z) complex participates in the hedgehog signaling pathway.Semantic proximity Read ↗

Functional analysis of mouse Polycomb group genes.Semantic proximity Read ↗

Nucleotide substitutions revealing specific functions of Polycomb group genes.Semantic proximity Read ↗

Polycomb group proteins ESC and E(Z) are present in multiple distinct complexes that undergo dynamic changes during development.Semantic proximity Read ↗

Genetic interactions and dosage effects of Polycomb group genes of Drosophila.Semantic proximity Read ↗

Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.